Connection Between Cocaine Use And Angina Essay

Use APA 6th Edition Format and support your work with at least 3 peer-reviewed references within 5 years of publication. Remember that you need a cover page and a reference page. All paragraphs need to be cited properly. Please use headers. All responses must be in a narrative format and each paragraph must have at least 4 sentences. Lastly, you must have at least 2 pages of content, no greater than 4 pages, excluding cover page and reference page.Connection Between Cocaine Use And Angina Essay

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Case Study is Due Date is extended 7/3/2020 by 12 Midnight. If submitted after 7/3/2020, points will be deducted. If Any questions, please do not hesitate to contact me.

Chronic Stable Angina

E.H. is a 45-year-old African American man who recently moved to the community from another state. He requests renewal of a prescription for a calcium channel blocker, prescribed by a physician in the former state. He is unemployed and lives with a woman, their son, and the woman’s 2 children. His past medical history is remarkable for asthma and six “heart attacks” that he claims occurred because of a 25-year history of drug use (primarily cocaine). He states that he used drugs as recently as 2 weeks ago. He does not have any prior medical records with him. He claims that he has been having occasional periods of chest pain. He is unable to report the duration or pattern of the pain. Before proceeding, explore the following questions: What further information would you need to diagnose angina (substantiate your answer)? What is the connection between cocaine use and angina? Identify at least three tests that you would order to diagnose angina.Connection Between Cocaine Use And Angina Essay

Diagnosis: Angina

1. List specific goals of treatment for E.H.

2. What dietary and lifestyle changes should be recommended for this patient?

3. What drug therapy would you prescribe for E.H. and why?

4. How would you monitor for success in E.H.?

5. Describe one or two drug–drug or drug–food interactions for the selected agent.

6. List one or two adverse reactions for the selected agent that would cause you to change therapy.

7. What would be the choice for the second-line therapy?

8. Discuss specific patient education based on the prescribed first-line therapy.

9. What over-the-counter and/or alternative medications would be appropriate for E.H.?Connection Between Cocaine Use And Angina Essay

Cocaine is the second commonest illicit drug used and the most frequent cause of drug related deaths. The younger age group of 18–25 are the most common users and it is estimated that 11% of the population has used it at some point.1,2 Cocaine may be taken by smoking, nasal inhalation, or injection with varying pharmacokinetics leading to peak blood concentration ranging from 1 to 90 minutes. Its use is associated with both acute and chronic complications that may involve any system, the most common being the cardiovascular system.2–4 Complications can also follow any route of administration.5 It is worth noting that pre-existent vascular disease or other abnormalities are not a prerequisite for the development of cocaine related cardiovascular complications.5

Cocaine misuse and its related morbidity are important and have to be considered on the differential diagnosis of cardiovascular events in young adults because of its major effect and the resulting loss of productivity and undue morbidity with its related cardiac and cerebrovascular events.Connection Between Cocaine Use And Angina Essay

Cocaine related complications include

Cardiac: myocardial ischaemia, coronary artery spasm, acute myocardial infarction (MI), atherosclerosis, myocarditis, cardiomyopathy, arrhythmia, hypertension, and endocarditis.

Vascular: aortic dissection and rupture, vasculitis.6

Gastrointestinal: mesenteric ischaemia or infarction, perforation.7

Pulmonary: pulmonary oedema, pulmonary infarction, and haemoptysis.8

Genitourinary and obstetric: renal and testicular infarction, abruptio placentae, spontaneous abortion, prematurity, and growth retardation.9

Neurological: seizures, migraine, cerebral infarction, and intracranial haemorrhage.10

Musculoskeletal and dermatological: rhabdomyolysis, skin ischaemia, superficial and deep venous thrombosis, and thrombophlebitis.11

In this review we will focus on the cardiovascular effects of cocaine.Connection Between Cocaine Use And Angina Essay

PHARMACOLOGY OF COCAINE
Cocaine (benzoylmethylecgonine, C17, H21, NO4) is an alkaloid extract from the leaf of the Erythroxylon coca plant, which usually grows in South America. It is available in two forms:

Hydrochloride salt: prepared by dissolving the alkaloid in hydrochloric acid forming a water soluble powder or granule that decomposes when heated. It can be taken orally, intranasally, or intravenously.

Free base: manufactured by processing the cocaine with ammonia or sodium bicarbonate (baking soda). It is a heat stable form that melts with temperature allowing it to be smoked and it is known as “crack” because of the popping sound it makes when heated. Crack cocaine is considered the most potent and addictive form.Connection Between Cocaine Use And Angina Essay

Cocaine is absorbed, in both forms, from all body mucus membranes. The peak effect ranges from 1 to 90 minutes depending on the route of administration. The half life ranges from 60 minutes after inhalation or intravenous injection to two to three hours after gastrointestinal ingestion, with duration of action between 15 minutes by intravenous or inhalation routes to three hours by the gastrointestainal route.5 (table 1).

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Table 1
Pharmacokinetics of cocaine according to the route of administration

Cocaine is metabolised to inactive water soluble metabolites (benzoylecgonine and ecgonine methyl ester) by hepatic and plasma cholinesterase and also by non-enzymatic hydrolysis. The elderly population, people with liver disease, the fetus, infants, pregnant women, and adults with pseudicholinesterase deficiency have lower cholinesterase activity and thus carry an increased risk with cocaine. The concomitant use of cocaine and alcohol, a common practice in young users, has a dangerous and multiplicative cardiovascular risk. They are metabolised in the liver to cocaethylene, which has been associated with a 40-fold increase in risk for acute cardiac events and 25-fold increase in sudden death.Connection Between Cocaine Use And Angina Essay

Cocaine water soluble metabolites are excreted in the urine,13 which remains positive for cocaine metabolite up to 72 hours, providing an indicator of recent cocaine use.14,15 Norcocaine is formed by an N-demethylation reaction, and represents less than 5% of the total quantity of cocaine metabolites. It may mediate delayed effects of cocaine via enterohepatic recirculation.16 Cocaine use can also be detected by hair analysis, which is a sensitive marker and provides information about cocaine use in the preceding weeks or months, depending on the length of the hair analysed.9 Interestingly, the prevalence of cocaine use is three to five times more than in standard surveys and interview with patients, when hair analysis was used.17,18

MECHANISM OF ACTION
Cocaine acts as a powerful sympathomimetic agent. It blocks the presynaptic reuptake of norepinephrine and dopamine producing high level of these neurotransmitters at the postsynaptic receptors.2 Cocaine also may increase the release of catecholamines from central and peripheral stores.19 It can act as a local anaesthetic by blocking the initiation and transmission of electrical signals, as it inhibits membrane permeability to sodium during depolarisation.20 The arrythmogenic potential of cocaine has led to the decline in its use in ear, nose, eye, and throat surgery.Connection Between Cocaine Use And Angina Essay

Cocaine produces a dose dependent increase in blood pressure and heart rate, which, in recreational doses, usually remains within the physiological range.21 The sympathomimetic actions of cocaine, at cellular level, are mediated by stimulation of the α and β adrenergic receptors. Cocaine also interacts with the muscarinic receptors,22 and inhibits the reuptake of dopamine and seretonin by nerve endings.

CARDIOVASCULAR EFFECTS OF COCAINE USE
The most common symptom in cocaine users is chest pain,4 and the most common cardiac disorders is ischaemia and acute coronary syndrome, which can occur with all routes of cocaine intake.23,24 Other cardiac problems include myocarditis, cardiomyopathy, and arrhythmias.

COCAINE RELATED CHEST PAIN AND MYOCARDIAL INFARCTION
The commonest cocaine related cardiovascular problem is chest pain with 57% of these patients admitted to the hospital.Connection Between Cocaine Use And Angina Essay

Myocardial infarction after cocaine use involves several mechanisms. It is related to the block of the re-uptake of norepinephrine that leads to α and β adrenergic effects. These include increased heart rate and blood pressure and simultaneous coronary vasospasm with reduced oxygen delivery leading to myocardial ischaemia.19 In addition, there is evidence that cocaine activates platelets, increases platelets aggregability, and potentiates thromboxane production promoting thrombus formation.26–28

Acute coronary events and MI can occur minutes after cocaine administration or as late as few days afterwards.24 The highest risk is in the first hour after cocaine use with no relation to the dose or route of administration.24,29 Cocaine induced MI often occurs in patients with normal coronary arteries and the typical patient is described as a man in his 30s with only smoking as a coronary risk factor.29–32 Half of these patients would have experienced chest pain previously.24 Interestingly, the anterior wall is involved in most cases (77%) of cocaine induced MI.31 Chest pain and ECG changes are very common in cocaine users even in the absence of myocardial ischaemia and MI31 and only 6% of cocaine induced chest pain are attributable to MI.Connection Between Cocaine Use And Angina Essay

The risk of MI is increased up to 24 times over baseline in the first 60 minutes after cocaine use. In one series, 1% of patients who had an acute MI, had used cocaine within the previous year. Of this group, about 25% used cocaine within 60 minutes before the infarct.29

Young patients presenting with chest pain and suspected acute coronary syndrome should be questioned about cocaine use.

Cocaine induced MI can be difficult to diagnose accurately, as the ECG is difficult to interpret in young patients, with the high incidence of early repolarisation and left ventricular hypertrophy. On the other hand, MI can occur with normal ECG or with only non-specific findings. Up to 84% of patients with cocaine induced chest pain may have an abnormal ECG and up to 43% of cocaine misusers without MI may have ST segment elevation in two or more ECG leads that may even meet the thrombolysis criteria.25,32,33 The reported ECG sensitivity for detecting cocaine induced MI is 36% with a 90 % specificity.Connection Between Cocaine Use And Angina Essay

Serum creatine kinase is not a reliable indicator of myocardial injury and is increased in almost half of cocaine users without MI. This is thought to be attributable to rhabdomyolysis. In contrast, cardiac troponins are more sensitive and specific for myocardial injury and should be used for the diagnosis of MI.33–36

Complications after cocaine induced MI, fortunately, have a low incidence, possibly because of the young age of most patients, and occur mostly within 12 hours of presentation. Ventricular arrhythmias occur in 4% to 17%, congestive heart failure in 5% to 7%, and death in less than 2%. However, continuous cocaine use and recurrent chest pain are common, with occasional recurrent non-fatal MI or death.37,38

CARDIAC ARRHYTHMIAS
A wide range of benign and malignant arrhythmias has been reported with cocaine use. The arrhythmias are usually transient and resolves when cocaine is metabolised. Sinus tachycardia and bradycardia, supraventricular arrhythmias, bundle branch block, ventricular fibrillation or asystole, ventricular tachycardia, and torsade de pointes have all been reported.Connection Between Cocaine Use And Angina Essay

The autonomic imbalance and the changed cardiac automaticity, caused by the high adrenergic state, are thought to trigger arrhythmia.30,42 Re-enterant tachycardia may also result from the electrical inhomogeneity caused by the cocaine induced ischaemia.43 On the other hand, cocaine can lead to prolongation of the QRS and QTc duration, like class IA antiarrythmic agents, hence a deleterious combination with other agents that prolong QTc.

CARDIOMYOPATHY AND MYOCARDITIS
Dilated cardiomyopathy has been reported in cocaine users and is thought to be attributable to the direct toxic effects of cocaine on the heart leading to heart failure because of myofibrils destruction, interstitial fibrosis, and myocardial dilatation. The cocaine induced hyperadrenergic state may also contribute to the cardiomyopathy,44 similar to that seen in pheochromocytoma.

Myocarditis was reported in 20% to 30% of patients dying from cocaine misuse, as well as on myocardial biopsies of active users.42,44,45 The mechanism is thought to be either secondary to hypersensitivity reactions leading to vasculitis and myocarditis, or attributable to catecholamine induced cardiac toxicity.Connection Between Cocaine Use And Angina Essay

Fortunately, myocardial dysfunction is reversible with abstinence, so is cocaine induced myocarditis in its early stages.46–49

Heart failure and cardiomegaly in a young person should raise the possibility of cocaine misuse.50

STROKE
The risk of stroke is considerably increased with cocaine use.51,52 Cerebral ischaemia and stroke result from multiple factors, similar to myocardial ischaemia. Cocaine causes vasospasm, because of high levels of monoamines (dopamine),53,54 and may cause thrombus formation leading to cerebral ischaemia,55 which leads to hypoperfusion and neurological deficits. Long term cocaine use can also lead to cognitive deficits.56 Cocaine can also lead to rupture of pre-existing cerebral and mycotic aneurysms.

The risk of cerebral haemorrhage is increased with continuous cocaine use, because of weakened vessel walls that result from the repeated ischaemic episodes and reperfusion. Dihydropyridine calcium channel blockers may prevent cocaine induced cerebral vasospasm.Connection Between Cocaine Use And Angina Essay

ENDOCARDITIS
Cocaine use seems to be a greater independent risk factor for developing endocarditis than the use of other drugs and the endocarditis associated with cocaine misuse, in contrast with endocarditis associated with other drugs, often involves the left sided cardiac valves.58 It is presumed that the increase in heart rate and blood pressure that result from cocaine use may lead to valvular and vascular injury that predisposes to bacterial invasion, as well as the immunosuppressive effects of cocaine that may increase the risk of infection.59

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AORTIC DISSECTION
The use of crack cocaine can lead to acute aortic dissection.60 Dissection results probably from the increase in systemic arterial pressure caused by cocaine and should be considered as a possible cause of chest pain in cocaine users.61,62

MANAGEMENT OF COCAINE RELATED CHEST PAIN
Recognising that ischaemia or infarction is attributable to cocaine use is critical for optimal management.Connection Between Cocaine Use And Angina Essay

The first line treatment in patients with chest pain and ECG changes after cocaine use, according the AHA/ACC guidelines, is benzodiazepines, aspirin, and nitrates.36 Benzodaizepines reduce blood pressure and heart rate and are recommended especially in patients with associated hypertension, tachycardia, or anxiety. Aspirin prevents thrombus formation and nitrates reverse cocaine induced coronary vasoconstriction. Oxygen also should be given and would help in limiting myocardial ischaemia.Connection Between Cocaine Use And Angina Essay

Calcium channel blockers and α blockers can be added as a second line treatment.63–65 Thrombolytic therapy should be used with caution and only if signs of infarction persist.32,36

The use of β blockers can be deleterious and should be avoided in the acute stage, as their use may worsen vasospasm by permitting unopposed stimulation of α receptors.66 Labetalol, which has a combined α/β blocker effect, was shown to reduce the rise in blood pressure with no effect on cocaine induced coronary vasoconstriction.Connection Between Cocaine Use And Angina Essay

The use of thrombolytic therapy in patients with cocaine related infarction remains controversial. It should be restricted to patients who have continued evidence of evolving MI despite the administration of first line medical treatment,2,36,68 and when immediate coronary angiography and angioplasty are not available, as experience with thrombolytic therapy in this clinical scenario is limited with reports of catastrophic complications associated with its use in cocaine users,69,70 in addition to the difficulty in identifying MI by standard ECG criteria.33 Primary percutaneous coronary intervention may be a safer approach in those with definite MI, especially in the presence of cocaine use complications such as severe hypertension, seizures, intracerebral haemorrhage, or aortic dissection. Connection Between Cocaine Use And Angina Essay

The proarrhythmic and proconvulsant effects of antiarrhythmic drugs may be additive to that of cocaine and their use should be cautious. The use of sodium bicarbonate for cocaine induced conduction abnormalities and rhythm disturbance is being evaluated.25

The mechanism of MI and the high prevalence of chest pain without MI have important implications in management decisions. Not all patients who come to hospital with chest pain after cocaine use will need to be admitted. A recent study suggested that a 12 hour observation period with serial ECG and cardiac enzymes would be safe and reasonable to rule out acute MI and select patients who need to be admitted.71 This approach is expected to be highly cost effective.Connection Between Cocaine Use And Angina Essay

The incidence of late complications among patients, admitted with cocaine related chest pain, and in whom MI has been ruled out, seems low. In one study the one year survival was 98% and the incidence of late MI was around 1%.38 About two thirds of patients (60%) admitted with cocaine associated chest pain continue to use cocaine in the year after the symptomatic episode.38

CONCLUSION
The recognition of cocaine induced ischaemia or MI is crucial for optimal management. A previously healthy young person presenting with cardiac type chest pain or MI should be asked about cocaine use. Many cocaine users have little or no idea of the risks associated with its use. Patients, health care professionals, and the public should be educated about the dangers and the considerable risks of cocaine use. People with cocaine misuse or dependence, particularly young men, should be encouraged to stop and should be referred for rehabilitation. Connection Between Cocaine Use And Angina Essay

Cocaine is among the most commonly used illicit recreational drugs worldwide. Because even casual use of cocaine may be associated with acute or chronic cardiovascular toxicity, the large numbers of exposed individuals may present with sequelae related to the cardiovascular system. Thus, the cardiovascular history should include questions about cocaine use, specifically focusing on symptoms associated with ischemic heart disease.
Cocaine use is more frequently associated with acute rather than chronic cardiovascular illness. Among cocaine users who present to emergency departments, cardiovascular complaints, particularly chest pain, are common [1,2]. In such patients, acute coronary syndromes (including myocardial ischemia and infarction), aortic dissection and rupture, arrhythmias, myocarditis, and vasculitis need to be considered [3].Connection Between Cocaine Use And Angina Essay

The cardiovascular effects and complications of cocaine use, as well as the management of cocaine-associated ischemia, will be reviewed here. Other issues relating to cocaine use, including the general approach to patients with chest pain and a history of cocaine use, are discussed elsewhere. (See “Cocaine use disorder in adults: Epidemiology, pharmacology, clinical manifestations, medical consequences, and diagnosis” and “Cocaine: Acute intoxication”.)Connection Between Cocaine Use And Angina Essay

CARDIOVASCULAR PHYSIOLOGIC EFFECTS OF COCAINE

The major cardiovascular effects of cocaine appear to be caused by the inhibition of norepinephrine reuptake into the synaptic cleft by sympathetic neurons, although sodium channel blockade and stimulation of excitatory amino acids likely also contribute to the effects [2]. Since reuptake is the major mechanism by which neurotransmitters are removed from active receptor sites, this inhibition results in potentiation of the response to sympathetic stimulation of innervated organs and to infused catecholamine. Cocaine may also enhance the release of catecholamines from central and peripheral stores [4,5]. The ensuing sympathomimetic actions (increased myocardial inotropy, heart rate, systemic blood pressure, and coronary artery constriction primarily at the capillary level) are mediated by stimulation of the alpha- and beta-adrenergic receptors and result in increased myocardial oxygen demand and decreased myocardial perfusion. (See “Cocaine: Acute intoxication”, section on ‘Pathophysiology’.)
Other cardiovascular effects of cocaine include promotion of thrombus formation (via activation of platelets, stimulation of platelet aggregability, and potentiation of thromboxane production) and proarrhythmia [6-8]. The cardiovascular effects produced by intravenous, intranasal, and inhaled cocaine are thought to be similar regardless of the route of ingestion Connection Between Cocaine Use And Angina Essay