Frontiers in Pharmacology Paper

Hepatobiliary and Gastrointestinal disorders are caused by insufficient lipid absorption resulting from dysfunctional enterocytes. These disorders are attributed to the decrease in the number of enterocytes in the body and lack of biliary secretion that cause malabsorption of dietary vitamin. Due to this pathophysiology, the body experiences deficiency of vitamin D (Schmutz et al., 2017). An example of a gastrointestinal disorder is the Acute gastroenteritis that is associated with viral pathogens that cause diarrhea, nausea, weight loss, vomiting, and dehydration in patients.Frontiers in Pharmacology Paper

In this paper, the diagnosis and plan for drug therapy for a patient named HL will be presented. HL is a patient who has shown symptoms of vomiting, nausea, diarrhea, and shows a history of abusing drugs in the past. His medical history shows possible signs of hepatitis C and has a drug medication history of synthroid 100 mcg, prednisone 10 mg, and nifedipine 30 mg. Acute GE is associated with high mortality rate among patients of all ages dispute it being a self-limiting diarrheal disease (Schmutz et al., 2017).

The symptoms presented by HL indicate that he could be diagnosed with acute gastroenteritis. The inflammation of HL’s stomach, GI tract, and the intestines could be attributed to infection by parasites, viruses, or bacteria. The diarrhea and nausea that HL experiences will possible lead to fever and lack of energy due to dehydration. Therefore, the most appropriate drug therapy plan for HL is;

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• An NPO (Nil per Oral) for 24 hours
• IV fluids intake to facilitate bowel resting (Arcangelo et al., 2017).
• Administer 0.9% IV Normal Saline fluid replacement.
• Administer hourly doses of Phenergan, 12.5mg-25 mg IV every 4-6 to relieve nausea (Kang, 2016).
• Administer an initial dose of 4mg then 2 mg Imodium after the first stool followed by loose motion (maximum daily dose 16 mg) (Zollner-Schwetz & Krause, 2015).
• Educate HL on prevention measure so that he understands the essence of maintaining hand and food hygiene

References

Arcangelo, V. P., Peterson, A. M., Wilbur, V. F., & Reinhold, J. A. (2017). Pharmacotherapeutics for advanced practice: a practical approach. Philadelphia: Wolters Kluwer

Kang, G. (2016). Therapy of Viral Gastroenteritis. In Viral Gastroenteritis (pp. 73-88). Academic Press.

Schmutz, C., Bless, P. J., Mäusezahl, D., Jost, M., Mäusezahl-Feuz, M., & Swiss Sentinel Surveillance Network (2017). Acute gastroenteritis in primary care: a longitudinal study in the Swiss Sentinel Surveillance Network, Sentinella. Infection, 45(6), 811–824. https://doi.org/10.1007/s15010-017-1049-5

Zollner-Schwetz, I., & Krause, R. (2015). Therapy of acute gastroenteritis: role of antibiotics. Clinical Microbiology and Infection, 21(8), 744-749.

Assignment: Pharmacotherapy for Gastrointestinal and Hepatobiliary Disorders

Gastrointestinal (GI) and hepatobiliary disorders affect the structure and function of the GI tract. Many of these disorders often have similar symptoms, such as abdominal pain, cramping, constipation, nausea, bloating, and fatigue. Since multiple disorders can be tied to the same symptoms, it is important for advanced practice nurses to carefully evaluate patients and prescribe a treatment that targets the cause rather than the symptom. Frontiers in Pharmacology Paper

Once the underlying cause is identified, an appropriate drug therapy plan can be recommended based on medical history and individual patient factors. In this Assignment, you examine a case study of a patient who presents with symptoms of a possible GI/hepatobiliary disorder, and you design an appropriate drug therapy plan.

To Prepare

• Review the case study assigned by your Instructor for this Assignment
• Reflect on the patient’s symptoms, medical history, and drugs currently prescribed.
• Think about a possible diagnosis for the patient. Consider whether the patient has a disorder related to the gastrointestinal and hepatobiliary system or whether the symptoms are the result of a disorder from another system or other factors, such as pregnancy, drugs, or a psychological disorder.
• Consider an appropriate drug therapy plan based on the patient’s history, diagnosis, and drugs currently prescribed.

Write a 1-page paper that addresses the following:

• Explain your diagnosis for the patient, including your rationale for the diagnosis.
• Describe an appropriate drug therapy plan based on the patient’s history, diagnosis, and drugs currently prescribed.
• Justify why you would recommend this drug therapy plan for this patient. Be specific and provide examples.

Frontiers in Pharmacology Paper