The Management Of Stimulant Use Disorder Discussion

Discussion week 4

Pharmacological intervention

There is currently no FDA-approved pharmacotherapy treatment for cocaine disorders according to, (Chan et al., 2018).  Even though some drugs often show encouraging data for the treatment of stimulant use disorder, the evidence remains uncertain and application is limited. The Management Of Stimulant Use Disorder Discussion

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Dopamine agonist

It has been used to successfully treat tobacco and opioid use disorders. In agonist treatment, the drug activates the similar effects as the abused drug thus bearing the same effects but have pharmacological properties that portray it less abusable than the abused drug. Ideally drugs which penetrate the brain more slowly tend to have a prolonged duration of action or are partial agonist rather than full agonist and are known to have less addictive potential (Kampman, 2019). Long-acting amphetamine has been used in various clinical trials and is showing promising results.

Cholinergic medications

Galantamine is a reversible and competitive behavior of acetylcholinesterase that increases the acetylcholine levels in the synaptic cleft leading to stimulation of both muscarinic and nicotinic receptors. Research studies have shown that disruption in the cholinergic system is linked with cocaine use and thus, galantamine might be useful in the management of cocaine abuse.

Noradrenergic agents

Doxazosin is a long-acting selective alpha-a adrenergic antagonist that decreases central noradrenergic activity which reduces the behavioral effect of stimulants. The Management Of Stimulant Use Disorder Discussion

Non-pharmacological intervention

Psychosocial treatment has been proven to be more beneficial. Psychotherapy; including drug counseling, CBT, and recurrence prevention is recommended as the mainstay treatment plan for stimulant addiction (Kampman, 2019). Contingency management strategies are among the most promising approaches in the management of stimulant use disorder as it utilizes ‘manipulative’ enforcement to accomplish the specific goal of short-term drug abstinence. The reinforcement includes; the using vouchers for goods and services or financial rewards. This method is effective in various clinical trials. On the other hand, CBT mainly concentrates on learning strategies that will help change maladaptive behaviors and increase coping skills with relapse prevention being a common goal. The Management Of Stimulant Use Disorder Discussion

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References

Chan, B., Kondo, K., Ayers, C., Freeman, M., Montgomery, J., Paynter, R., & Devan Kansagara. (2018, August). Pharmacotherapy for Stimulant Use Disorders: A Systematic Review. Nih.gov; Department of Veterans Affairs (US). https://www.ncbi.nlm.nih.gov/books/NBK536789/

‌ Kampman, K. M. (2019). The treatment of cocaine use disorder. Science Advances, 5(10). https://doi.org/10.1126/sciadv.aax1532 The Management Of Stimulant Use Disorder Discussion